Shadow and substance: restoring the literary output of Robert Pearse Gillies (1789–1858)

Late in life in in his Memoirs of a Literary Veteran (1851) R. P. Gillies reflected on a career fraught with difficulties owing to debt and other obstacles, though in it earlier stages it might be said to have paralleled in some respects the path of Walter Scott, while reaching a highpoint in the 1820s through Gillies’s significant input as a Germanist into Blackwood’s Edinburgh Magazine. One deep regret as expressed in the Memoirs was his eventual incapacity to piece together his own literary record owing to the loss of materials at significant points in his life. The present article attempts to ameliorate this situation by providing a fuller record than was then available to Gillies himself, through means such as the recovery of rare editions, identification of periodical contributions, and information provided by the archives of the Royal Literary Fund. More particularly it offers an improved account of Gillies’s output as a novelist and translator of fiction, with some newly identified titles being added to the list, while others are removed

The English Novel, 1800–1829 & 1830–1836: Update 7 (August 2009–July 2020)

This report, like its predecessors, relates primarily to the second volume of The English Novel, 1770–1829: A Bibliographical Survey of Prose Fiction Published in the British Isles (Oxford: OUP, 2000) [EN2], co-edited by Peter Garside and Rainer Schöwerling, with the assistance of Christopher Skelton-Foord and Karin Wünsche. It also refers to the online The English Novel, 1830–36: A Bibliographical Survey of Fiction Published in the British Isles [EN3], which effectively serves as a continuation of the printed Bibliography

The English novel, 1800–1829 & 1830–1836: update 8 (April 2000–June 2023)

This report, like its predecessors, relates primarily to the 2nd vol. of The English Novel, 1770–1829: A Bibliographical Survey of Prose Fiction published in the British Isles (2000) and the online The English Novel 1830–1836. The procedure followed derives generally from the activities of the research team who helped produce The British Novel 1800–1829: A Database of Production, Circulation, and Reception, first made publicly available in 2004, though only materials found in Updates 1–4 are incorporated in that database. The present report comes twenty-three years since the release in March 2000 of the printed Bibliography, and some nineteen years after the original launch of British Fiction 1800–1829 database. Its primary aim is to consolidate all the preceding seven Updates into one final composite statement, while at the same time, in assembling these materials, reference has been made to a number of additional sources, incorporating further new information

Being the ‘med reg’: an exploration of junior doctors’ perceptions of the medical registrar role

The role of the medical registrar is a challenging one and is acknowledged as being a disincentive to a career in medicine for some junior doctors. We set out to build a broader understanding of the role through exploration of Foundation Doctors’ and Core Medical Trainees’ perceptions of the role. Data, gathered from focus groups, were analysed using a framework approach. Six key themes were identified, which were grouped under the headings ‘perceptions of the medical registrar role’ and ‘transition into the role’. Our work builds on existing literature to inform a deeper understanding of how junior doctors perceive the medical registrar role. In light of our findings we offer suggestions on possible training initiatives to tackle the issues identified. We also highlight positive perceptions of the role and emphasise the key ambassadorial role that current medical registrars have in relation to attracting tomorrows’ medical registrars to the specialty

Why geriatric medicine? A survey of UK specialist trainees in geriatric medicine

Background: There is global concern that there are insufficient numbers of geriatricians to meet the needs of the ageing population. A 2005 survey described factors that influenced why UK geriatricians had chosen to specialise in the field - in the decade since, UK postgraduate training has undergone a fundamental restructure. Objective: To explore whether the reasons for choosing a career in geriatric medicine in the UK had changed over time, with the goal of using this knowledge to inform recruitment and training initiatives. Design: An online survey was sent to all UK higher medical trainees in geriatric medicine. Methods: Survey questions that produced categorical data were analysed with simple descriptive statistics. For the survey questions that produced free-text responses, an inductive, iterative approach to analysis, in keeping with the principles of framework analysis, was employed. Results: 269 responses were received out of 641 eligible respondents. Compared with the previous survey, a substantially larger number of respondents regarded geriatric medicine to be their first-choice specialty and a smaller number regretted their career decision. A greater number chose geriatric medicine early in their medical careers. Commitments to the general medical rota and the burden of service provision were considered important downsides to the specialty. Conclusions: There are reasons to be optimistic about recruitment to geriatric medicine. Future attempts to drive up recruitment might legitimately focus on the role of the medical registrar and perceptions that geriatricians shoulder a disproportionate burden of service commitments and obligations to the acute medical take

Climate change and social learning (CCSL): supporting local decision making for climate change, agriculture and food security

The CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS1) is challenging its own community of scientists and partners to understand the importance of co-created knowledge in finding solutions to local climate change issues. Local communities dealing with the daily realities of climate change risk, adaptation and mitigation don’t have time to wait. They need an immediate way to combine their own knowledge with that of others to build better solutions. CCAFS believes it can use the concept of social learning to challenge the CGIAR family and others to adopt new ways of working, forge new partnerships and co-create new knowledge to support more collective local decision making on climate change

Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors

Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in aged Apoe−/− mice that artery TLOs (ATLOs) controlled highly territorialized aorta T cell responses. ATLOs promoted T cell recruitment, primed CD4+ T cells, generated CD4+, CD8+, T regulatory (Treg) effector and central memory cells, converted naive CD4+ T cells into induced Treg cells, and presented antigen by an unusual set of dendritic cells and B cells. Meanwhile, vascular smooth muscle cell lymphotoxin β receptors (VSMC-LTβRs) protected against atherosclerosis by maintaining structure, cellularity, and size of ATLOs though VSMC-LTβRs did not affect secondary lymphoid organs: Atherosclerosis was markedly exacerbated in Apoe−/−Ltbr−/− and to a similar extent in aged Apoe−/−Ltbrfl/flTagln-cre mice. These data support the conclusion that the immune system employs ATLOs to organize aorta T cell homeostasis during aging and that VSMC-LTβRs participate in atherosclerosis protection via ATLOs